We analyzed the results of the prostate biopsies of 64 patients with elevated serum PSA (>4ng/ml) at Kangbuk Samsung Hospital from March 1993 to February 1996.
Of 64 patients 11 patients (17%) had prostate cnacer and 53 patients (83%) were diagnosed as benign prostatic hyperplasia. Among patients with prostate cancer, 1 patient had serum PSA between 4.1 to 10.0ng/ml, 2 patiens between 10.1 to 20.0ng/ml
and 8
patients above 20ng/ml. The detection rates of prostate canter in each serum PSA levels were 3%, 15% and 36% respectively.
Two of 17 patients with both negative DRED and TRUS were diagnosed as prostate cnacer. Two of 21 patients with positive TRUS and negative DRE had prostate cnacer but none of 8 patients with positive DRE and negative TRUS had prostate cnacer.
Seven
of 18
patients with both positive TRUS and DRE had prostate prostate cancer. The sensitivity, specificity, positive predictive value and overall accuracy of DRE and TRUS in patients with elevated PSA (>4ng/ml)k were 64%, 64%, 27%, 64% and 82%, 43%,
23%,
50%
respectively in patients with elevated serum PSA (>4ng/ml).
In conclusion, these results suggest that prostate biopsy in early diagnosis of prostate cancer would be needed for the patients with elevated serum PSA (>4ng/ml) regardless of the results of ERE and TRUS.
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